After Alfie (Anthony Hopkins) leaves Helena (Gemma Jones) to pursue his lost youth and a free-spirited call girl named Charmaine (Lucy Punch), Helena abandons rationality and surrenders her life to the loopy advice of a charlatan fortune teller.

Unhappy in her marriage, Sally (Naomi Watts) develops a crush on her handsome art gallery owner boss, Greg (Antonio Banderas), while Roy (Josh Brolin), a novelist nervously awaiting the response to his latest manuscript, becomes moonstruck over Dia (Freida Pinto), a mystery woman who catches his gaze through a nearby window.