In the film a mysterious and seemingly global blackout causes countless populations to simply vanish, leaving only their clothes and possessions behind. A small handful of survivors band together in a dimly-lit tavern on 7th Street, struggling to combat the apocalyptic horror. Realizing they may in fact be the last people on earth, the darkness hones in on them alone.

John Leguizamo will be at this year's Toronto International Film Festival to premiere "Vanishing on 7th Street," in which he plays a film projectionist who finds people starting to disappear all around him.