Based on a true story, Séraphine delves into the relationship between naïve painter Séraphine Louis (1864–1942) and art collector Wilhelm Uhde. In a little town north of Paris, Séraphine works as a maid for Madame Duphot, who rents an apartment to German art critic and dealer Wilhelm Uhde, an enthusiastic advocate of modern and primitive artists. In her spare time, Séraphine paints, with anything she can find – wine, mud, a mixture of fruits and flowers. When Wilhelm comes across one of her paintings, he is instantly mesmerized and insists that Séraphine show him the rest of her work. So begins a nurturing relationship that will expose Séraphine's work to the world. But as Séraphine paints her most inspired canvas, the power of her work leads her into the realms of madness.