A dejected music business executive forms a bond with a young singer-songwriter new to Manhattan.

Can a Song Save Your Life? Finds Gretta (Keira Knightley) alone in New York City after being heartbroken by her musician boyfriend (Adam Levine). She finds laughter and rejuvenation with a down-on-his-luck record producer (Mark Ruffalo) who recognizes her musical talent and opens up an entire city of possibility for both of them.